Airway inflammation and late asthmatic reactions.
نویسنده
چکیده
IW. Emerson RJ, Graham WGB, Davis GS. Mineral dust and cell rocovery from the bronchoalveolar lavage of healthy Vermont granite workers. Am Rev Respir Dis, 1985, 132, 393-399. 8. Vallyathan V, Shi X, Dalal N, Irr W, Castranova V. Generation of free radicals from freshly fractured silica dust. Potential role in acute silica-induced lung injury. Am Rev Respir Dis, 1988, 138, 12131219. 9. Lugano EM, Dauber JH, Elias JA, Bashey RI, Jimenez SA, Daniele RP. The regulation of lung fibroblast proliferation by alveolar macrophages in experimental silicosis. Am Rev Respir Dis, 1984, 129, 767771. 10. Craighead JE, Vallyathan NV. Cryptic pulmonary lesions in workers occupationally exposed to dust containing silica. J Am Med Assoc, 1980, 244, 1939-1941. 11 . Rockoff SD. Schwartz A. Roentgenographic underestimation of early asbestosis by International Labor Organization classification. Analysis of data and probabilities. Chest, 1988, 93, 1088-1091.
منابع مشابه
Arginase inhibition protects against allergen-induced airway obstruction, hyperresponsiveness, and inflammation.
RATIONALE In a guinea pig model of allergic asthma, using perfused tracheal preparations ex vivo, we demonstrated that L-arginine limitation due to increased arginase activity underlies a deficiency of bronchodilating nitric oxide (NO) and airway hyperresponsiveness (AHR) after the allergen-induced early and late asthmatic reaction. OBJECTIVES Using the same animal model, we investigated the ...
متن کاملThe modulatory effect of antigen- and PAF-induced asthmatic reaction by aerosol administration of OKY-046 in guinea pigs.
The therapeutic effect of a thromboxane A2 (TXA2) synthetase inhibitor on asthma is still controversial. This study was aimed at clarifying its effect on asthmatic reactions in guinea pigs. Both ovalbumin (OVA)- and platelet activating factor (PAF)-induced dual phase airway spasm and hyperreactivity in guinea pigs were used as the asthma model. Our results demonstrated that aerosol administrati...
متن کاملLevel of Nitric Oxide in Bronchoalveolar Lavage Fluid of Asthmatic Mice Model
Background: Asthma is a chronic inflammatory disease with multifactorial and complicated mechanisms. Elevated level of exhaled Nitric Oxide (NO) in asthma and other inflammatory lung diseases has led to many studies examining NO as a potential marker of airway inflammation. Objective: This study was designed to determine the level of NO in Bronchoalveolar Lavage (BAL) fluid during early and l...
متن کاملThe preventive effect of Brassica napus L. oil on pathophysiological changes of respiratory system in experimental asthmatic rat
Objective: Asthma is an airway complex disease defined by reversible airway narrowing and obstruction, chronic airway inflammation, airway hyperresponsiveness, and tissue remodeling. The purpose of this study was to determine the effect of Brassica napus L. (B. napus) on airway pathologic changes in a rat model of asthma. Materials and Methods: Twenty-four rats were divided into 4 groups: contr...
متن کاملFunctional genomics of the peripheral blood response to allergen inhalation challenge
Objective/purpose In asthmatic individuals, airway narrowing represents the early phase of the asthmatic response to allergen inhalation challenge, occurring within thirty minutes [1]. In 50-60% of allergic asthmatic adults, the early response is followed by the late phase asthmatic response, usually starting between 3-4 hours after allergen inhalation challenge [2], and characterized mainly by...
متن کاملEffects of salbutamol and enantiomers on allergen-induced asthmatic reactions and airway hyperreactivity.
Salbutamol consists of a racemic mixture of R- and S-salbutamol. R-salbutamol (levalbuterol) is the active bronchodilating enantiomer, whereas S-salbutamol is thought to be pharmacologically inactive or to exert adverse effects. This study evaluated the bronchoprotective effects of inhalation of therapeutically relevant doses of the racemate and individual enantiomers in guinea pigs. It was fou...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The European respiratory journal
دوره 3 3 شماره
صفحات -
تاریخ انتشار 1990